期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease

Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
下载PDF
导出
摘要 Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopami- nergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson＇s disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinso^s disease. Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopami- nergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson＇s disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinso^s disease.
作者 Nour Erekat Ahed Al-Khatib Muhammed Al-Jarrah
机构地区 Department of Anatomy Department of Pathology Department of Rehabilitation Sciences Fatima College of Health Sciences (FCHS)
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第6期616-621,共6页 中国神经再生研究（英文版）
基金 financially supported by the Deanship of Research at Jordan University of Science and Technology,Irbid,Jordan
关键词 nerve regeneration heat shock protein 90 Parkinson＇s disease exerecise soleus muscle gastrocnemius muscle skeletal muscle treadmill excise neural regeneration nerve regeneration heat shock protein 90 Parkinson＇s disease exerecise soleus muscle gastrocnemius muscle skeletal muscle treadmill excise neural regeneration
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献59

  • 1Al-Iarrah M, Pothakos K, Novikova L, Smirnova IV, Kurz MJ, Stehno-Bittel L, Lau YS (2007) Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration. Neuroscience 149:28-37.
  • 2Al-Iarrah M, Matalka I, Aseri HA, Mohtaseb A, Smirnova IV, Novikova L, Stehno-Bittel L, Alkhateeb A (2010) Exercise training prevents endometrial hyperplasia and biomarkers for endometrial cancer in rat model of type 1 diabetes. J Clin Med Res 2:207 - 214.
  • 3Al-Iarrah MD, Iamous M (2011) Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease. NeuroRehabilitation 28:359-363.
  • 4Ali A, Bharadwaj S, O'Carroll R, Ovsenek N (1998) HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus 00- cytes. Mol Cell Bioi 18:4949-4960.
  • 5Atalay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, Roy S, Hanninen 0, Sen CK (2004) Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol (1985) 97:605- 61l.
  • 6Benjamin IJ, McMillan DR (1998) Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res 83: 117 -132.
  • 7Bergen JL, Toole T, Elliott RG, 3rd, Wallace B, Robinson K, Maitland CG (2002) Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson's disease patients. NeuroRehabilitation 17:161-168.
  • 8Cakit BD, Saracoglu M, Gene H, Erdem HR, Inan L (2007) The effects of incremental speed-dependent treadmill training on postural instability and fear of falling in Parkinson's disease. Clin Rehabil21:698-705.
  • 9Chen Y, Noble EG (2009) Is exercise beneficial to the inflammatory bowel diseases? An implication of heat shock proteins. Med Hypotheses 72:84-86.
  • 10Conte M, Isolani ME, Deri P, Mannini L, Batistoni R (2011) Expression of hsp90 mediates cytoprotective effects in the gastrodermis of planarians. Cell Stress Chaperones 16:33-39.
Neural Regeneration Research
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部