双歧杆菌三联活菌胶囊辅助治疗幽门螺杆菌阳性消化性溃疡的疗效及安全性研究

Curative effect and safety of the adjuvant therapy of bifidobacterium bifidum-sine capsules to helicobacter pylori positive peptic ulcer

目的：探讨双歧杆菌三联活菌胶囊辅助治疗幽门螺杆菌（ HP）阳性消化性溃疡的疗效及安全性。方法选择76例HP感染的消化性溃疡患者，按数字表法随机分为观察组与对照组。对照组患者予以传统的奥美拉唑、阿莫西林和克拉霉素三联疗法治疗。观察组在此基础上加用双歧杆菌三联活菌胶囊420 mg，3次／d，两组的疗程均为4周。观察并比较两组患者治疗后临床症状缓解、溃疡愈合和HP清除率，并观察治疗期间的药物不良反应发生率，随访治疗后半年内及1年内消化性溃疡的复发率。结果观察组患者的HP清除率明显高于对照组（χ2＝4．21，P＜0．05）。观察组和对照组患者治疗期间分别发生药物不良反应4例（10.26％）和11例（29．73％），观察组患者的药物不良反应的发生率明显低于对照组（χ2＝4．55， P＜0.05）。对两组患者治疗后溃疡愈合者（观察组34例和对照组30例）治疗结束后随访观察半年和1年，观察组患者的溃疡复发率均明显低于对照组（χ2＝4．51，5．23，均P＜0．05）。结论双歧杆菌三联活菌辅助PPI三联疗法能提高消化性溃疡的HP根除率，能明显减少药物的不良反应，减少溃疡的复发率。

Objective To discuss the curative effect and safety of the adjuvant therapy （ AT） of bifidobacteri-um bifidum-sine capsules to helicobacter pylori （ HP） positive peptic ulcer .Methods 76 HP infected peptic ulcer patients were selected and divided into the observation group and control group at random .The patients in control group were given traditional triple therapy of omeprazole ,amoxicillin and carat enzyme for 4 weeks,while the patients in observation group were given bifidobacterium bifidum-sine capsules（420mg） three times daily for 4 weeks.Clinical symptom remission,ulcer healing and HP clearance of patients in two groups were observed and compared .The inci-dence rate of drug adverse reaction （ DAR） during treatment period was observed ,and the recurrence rates of peptic ulcer within half a year and one year were followed up .Results The HP clearance rate of the observation group was significantly higher than control group （χ2 =4.21,P〈0.05）.The incidence rate of DAR of the observation group was 10.26%,which was significantly lower than 29.73%of the control group （χ2 =4.55,P〈0.05）.34 cases in the ob-servation group and 30 cases in the control group were healed ,these patients were followed up for half a year and one year,and the recurrence rate of peptic ulcer in observation group was significantly lower than that in control group （χ2 =4.51,5.23,all P〈0.05）.Conclusion The bifidobacterium bifidum-sine capsules combined with PPI triple therapy,can increase the eradication rate of HP ,reduce DAR and the recurrence rate of ulcer .