阿托伐他汀钙联合维生素C对维持性血液透析患者微炎症反应的影响

Effects of atorvastatin calcium combined with vitamin C on the microinflammatory state in patients receiving maintenance hemodialysis

目的:研究阿托伐他汀钙联合维生素C对维持性血液透析(maintenance hemodialysis,MHD)患者微炎症状态的影响。方法:34例MHD半年以上的患者随机分为对照组(A组)、阿托伐他汀钙组(B组),以及维生素C+阿托伐他汀钙组(C组)。分别测定各组血脂指标TG、TC、LDL-C、HDL-C;营养指标Alb、PA和Hb,以及炎症因子CRP和IL-6。结果:治疗3个月后,B组、C组的TG、TC、HDL-C、LDL-C较治疗前具有明显改善(P<0.05)。营养指标在治疗3个月后,B组、C组患者的Alb、PA、Hb均逐渐升高,差异均有统计学意义(P<0.05),C组较B组改善的更为明显,差异具有统计学意义(P<0.05);炎症因子指标治疗后3个月CRP和IL-6水平较治疗前明显降低(P<0.05),C组较B组改善得更为明显,差异具有统计学意义(P<0.05)。结论:阿托伐他汀钙联合维生素C较能有效地改善MHD患者微炎症反应的影响。

Objective：To observe the effects of combined use of atorvastatin calcium with vitamin C on the microinflammatory state in patients under main-tenance hemodialysis（MHD）.Methods：Thirty-four patients receiving MHD over half a year were randomly allocated to atorvastatin group（Group A）,vita-min C group（Group B）and vitamin C plus atorvastatin group（Group C）.Each group were determined regarding the indicator lipids（including TG,TC, LDL-C,HDL-C）,nutrition index（including Alb,RA and Hb）and inflammatory factors（CRP and IL-6）.Results：After 3 months of therapy,the levels of TG,TC,HDL-C and LDL-C were significantly improved,and the nutrition indexes（Alb,PA,Hb）were gradually elevated in group B and C compared to pre-treatment（P＆lt;0.05）,and group C were more prominent than group B（P ＆lt;0.05）.The levels of CRP and IL-6 were distinctly decreased compared with those maintained 3 months before medication,with greater improvement in group C than group B（P＆lt;0.05）.Conclusion：Combined atorvastatin cal-cium with vitamin C may effectively inhibit the inflammatory response than single dosage of vitamin C for patients receiving MHD.