感染性荨麻疹33例临床分析

Severe acute urticaria: Clinical analysis in 33 cases

目的：总结感染性荨麻疹的临床特征，提高临床医生对感染性荨麻疹的认识。方法：回顾性分析2010年1月～2012年12月我院皮肤科与感染科合作诊治的33例感染性荨麻疹住院患者的病历资料。结果：感染主要来源于呼吸系统；单纯糖皮质激素治疗后病情急剧加重；中性粒细胞百分比和血清CRP水平均显著升高；积极抗感染同时辅以适量糖皮质激素和抗组胺药物治疗，病情均逐渐控制并痊愈出院。结论：对糖皮质激素治疗无效的急性荨麻疹患者应详细询问病史和体检，进行必要的实验室检查，积极寻找感染灶，尤其是上呼吸道感染。

Objective：To summarize the etiology and clinical features of severe acute urticaria for facilitating understanding of this disease .Methods：The history data were retrospectively examined in 33 inpatients with severe acute urticaria undergone cooperative treatment by both dermatology and infectious diseases departments in our hospital between January 2010 and December 2012.Results：Infection of the respiratory system was responsible for the attack of severe acute urticaria,which tended to be exacerbated by management of simple corticosteroids.Laboratory work showed that neutrophilic granulocyte counts and serum CRP levels were significantly elevated .The total patients were effectively managed with combined use of corticosteroid and antihistamin-ics.Conclusion：Patients with severe acute urticaria should undergo careful history taking and physical examination besides laboratory tests in the event of corticosteroid failure,to determine the focus of infection,especially upper respiratory tract infection.