右美托咪啶预防丙泊酚注射痛的效果

Outcomes of premedication with intravenous dexmedetomidine to attenuate the pain on injection of propofol

目的：观察右美托咪啶对丙泊酚注射痛的影响。方法：全麻下行择期外科手术患者60例，ASA分级Ⅰ～Ⅱ级，年龄19～65岁，体质量43．5～78 kg，随机数字表法分为两组（n＝30）：生理盐水组（S组，生理盐水0．15 ml/kg）、右美托咪啶组（D组，右美托咪啶0．6μg/kg），均为15 min完成恒速输注。随后静脉注射咪达唑仑0．06 mg/kg，2 min后，通过手背静脉以0．5 ml/s的速度注射丙泊酚。由一位不知具体分组情况的麻醉医生记录两组患者丙泊酚注射痛的发生情况。结果：两组患者一般资料差异无统计学意义；S组丙泊酚注射痛发生率为76．67％，D组无丙泊酚注射痛发生，D组丙泊酚注射痛发生率显著降低（P＜0．01）。结论：预先静脉注射右美托咪啶，联合咪达唑仑全麻诱导，可有效抑制丙泊酚注射痛的发生。

Objective：To evaluate the efficacy of dexmedetomidine in preventing the pain on injection of propofol .Methods：Sixty patients（ ASA Ⅰ-Ⅱ, aged 19-65 years,weighing 43.5-78 kg） undergone selective surgical procedures were randomized into either group of saline administration（group S） or pre-treatment with dexmedetomidine（group D）（n=30 for each）on computer-generated random number basis.Group S received normal saline in dose of 0.15 ml/kg,and group D were given dexmedetomidine in dose of 0.6 μg/kg via constant intravenous infusion within 15 min.After aforementioned treat-ment,the two groups were sequentially administered with intravenous injection of midazolam in dose of 0.06 mg/kg and propofol at speed of 0.5 ml/s via the dorsal veins of the hand 2 min later.Another anesthesiologist unware of the pretreatment was responsible for maintaining the incidence of the pain on injection of propofol.Results：The incidence of the pain on injection of propofol remained no difference regarding the demographic data ,yet 76.67% of the patients in group S reported pain and none of the patients had in group D,which was statistically significant（P＆lt;0.01）.Conclusion：Pretreatment with dexmedetomidine can effectively alleviate the pain on injection of propofol in general anesthesia induction by combined use of midazolam and propofol .