血宁治疗急性脑梗死的Meta分析

Treatment of acute cerebral infarction with Meta analysis

目的利用Meta分析方法评价舒血宁治疗急性脑梗死的临床疗效。方法对中国知网CNKI全文数据库、维普数据库、万方数据库进行查阅,2000年—2011年9月中国生物医学数据库公开发表的随机对照临床试验文献,并辅以手工检索,对纳入的试验结果采用RevMan 4.2软件进行Meta分析。结果共纳19篇文献资料。Meta分析结果显示,治疗组的临床疗效明显高于对照组,其差异有统计学意义[OR=4.15,95%CI(3.25,5.30),P<0.0000 1]。颅脑CT的变化中,治疗组改善率高于对照组,差异有统计学意义[OR=4.15,95%CI(2.74,6.27),P<0.0000 1]。两组治疗前后神经功能缺损评分比较中,治疗组优于对照组,其差异有统计学意义,[WMD=-4.52,95%CI(-5.82,-3.21),P<0.0000 1]。结论舒血宁治疗急性脑梗死有显著疗效,值得临床推广应用。

Objective To use Meta analysis method to evaluate the clinical effect on treatment of acute cerebral infarction. Methods To review China CNKI full-text database, Wanfang database, data base, Chinese biomedical databases from 2000 to 2011 September published randomized controlled clinical trials literature, supplemented by a manual search, using RevMan 4.2 software on the incorporation of the test results of the Meta analysis.Results a total of 19 references. Meta analysis results show, the curative effect of treatment group was significantly higher than that in the control group, the difference was statistically significant （OR=4.15, 95%C （ 3.25, 5.30）, P〈0.00001 ）. The changes of brain CT in treatment group improved, higher than that in the control group, the difference was statistically significant （OR = 4.15, 95%CI （ 2.74, 6.27）,P〈0.00001 ）. In two groups before and after treatment of nervous function defect score comparison, the treatment group was superior to the control group, the difference has statistical significance, （WMD = - 4.52, 95%CI （ - 5.82, - 3.21 ）, P〈0.00001 ）.Conclusion the treatment of acute cerebral infarction with significant effect, is worth the clinical promoted application.