多巴丝肼联合小剂量多奈哌齐对帕金森病患者认知功能及抑郁情绪的影响

Influence of levodopaand benserazide hydrochlo-ride combined with small dose of donepezil on cognitive function and depression of Parkinson's disease

目的探讨多巴丝肼联合小剂量多奈哌齐治疗帕金森病的临床疗效及对患者认知功能、抑郁情绪的影响。方法选择我院收治的帕金森病患者为研究对象,随机分为观察组和对照组,观察组采用多巴丝肼和小剂量多奈哌齐联合治疗,对照组仅常规给予多巴丝肼治疗。在治疗12周后,对比分析两组患者的临床疗效、认知功能及抑郁情绪改善情况。结果两组患者均顺利完成12周的治疗,两组患者显效率及总有效率差异无统计学意义(P>0.05);观察组患者MMSE评分和MoCA评分均较治疗前明显升高(P<0.01),而对照组患者MMSE评分和MoCA评分较治疗前明显降低(P<0.05),观察组患者治疗后MMSE评分和MoCA评分均明显高于对照组,差异均有统计学意义(P<0.01);两组患者HAMD评分均较治疗前明显降低(P<0.01),但观察组患者治疗后HAMD评分明显低于对照组,差异有统计学意义(P<0.01);治疗期间两组不良反应发生率分别为16.7%和11.9%,差异无统计学意义(P>0.05)。结论多巴丝肼联合小剂量多奈哌齐不仅能有效改善帕金森病症状,而且对改善患者认知功能和抑郁情绪同样具有重要作用,且不良反应少,具有良好的安全性,值得临床推广。

Objective To investigate the influence of levodopaand benserazide hydrochlo-ride combined with small dose of donepezil on cognitive function and depression of Parkinson′s disease. Methods The Parkinson′s pa-tients of our hospital were chosen and randomly divided into observation group and control group,observation group was treated with levodopaand benserazide hydrochlo-ride combined with small dose of donepezil, control group was treated with conventional dose of levodopaand benserazide hydrochlo-ride. After 12 weeks′ treatment,the clinical cura-tive effect,cognitive function and depression improvement of the two groups were compared. Results The patients of the two groups successfully completed 12 weeks treatment, the significant efficiency and total effective rate in both groups had no significant difference （P＆gt;0. 05）;MMSE score and MoCA score of observation group were significantly higher than those before treatment （P＆lt;0. 01）,while MMSE score and MoCA score of control group were significantly lower than those before treatment （P＆lt;0. 05）,MMSE score and MoCA score of observation group were significantly higher than those of the control group after treatment,the differences were significant （P＆lt;0. 01）;HAMD scores of the two groups were significantly lower than those before treatment （P＆lt;0. 01）,but the HAMD score of observation group was significantly lower than that of the control group after treatment,the difference was significant （P＆lt;0. 01）;During the treatment,the adverse reaction rate of the two groups were 16. 7% and 11. 9% respectively,there was no significant difference （P＆gt;0. 05）. Conclusion Levodopaand benserazide hydrochlo-ride combined with small dose of donepezil not only can effectively improve the symptoms of Parkinson′s disease,but also improve the cognitive function and de-pression and has less adverse reactions,worthy of clinical promotion.