福建省龙岩市2335例妇女宫颈HPV感染状况及基因型分析

Study on Human Papillomavirus Infection States and Genotypes of 2 335 Women in Longyan City,Fujian Province

目的：了解龙岩市妇女宫颈 HPV感染情况及 H PV基因亚型分布情况，为预防和治疗宫颈癌提供有价值的参考资料。方法：运用导流杂交基因芯片技术对2335例患者的宫颈分泌物标本进行21种 HPV基因亚型检测，并对2335例标本的 HPV 基因亚型感染情况进行对比分析。结果：自2335例宫颈分泌物标本中，共计检出563例 HPV呈阳性的标本，感染率为24．11％。在563例阳性标本中， HPV高危基因亚型感染频度的前5位依次为：H PV-52、-16、-58、-33及-31，阳性率分别为：26．82％、20．96％、13．68％、11．55％和5．86％。30～50岁是 HPV感染的高峰年龄段，HPV阳性检出率在各年龄组的差异有统计学意义（P＜0．05）。结论：运用导流杂交基因芯片技术进行 HPV基因分型检测对宫颈癌预防和治疗有较好的指导意义。

Objective ：To investigate the status of HPV infection and distribution of HPV genotypes in women in longyan Area and provide valuable data for preventing and treating uterine cervical cancer .Methods ：A total of 21 kinds of HPV genotypes infection were detected by flow-through hybridization and gene chip technique among 2 335 women , the infections status of subtypes of HPV were compared and analyzed Results：Among 2 335 cases ,563 cases were infec-ted HPV ,with the positive rate of 24 .11% .Among 563 cases ,the top five high-risk Subtypes of HPV were HPV-52 （26 .82% ） ,-16（20 .96% ） ,-58（13 .68% ） ,-33（11 .55% ） and-31（5 .86% ） .The peak age of HPV infection ranged from 30 to 50 years old .There were statistical significance among the HPV positive rates in different age groups （P〈0.05） . Conclusion：HPV genotyping detection is meaningful for preventing and treating uterine cervical cancer .