孟鲁司特治疗小儿持续性哮喘的疗效观察

Research on the Efficacy of Montelukast in the Treatment of Children with Persistent Asthma

目的探讨孟鲁司特治疗小儿持续性哮喘的临床疗效。方法选取我院儿科门诊于2012年3月至2012年5月收治的96例轻、中度持续性哮喘患儿为研究对象,将其随机分为两组,即对照组和观察组各48例。对照组患儿采用常规综合治疗,即布地奈德气雾剂治疗,观察组患儿在常规综合治疗的基础上附加孟鲁司特治疗。对两组的短期疗效、长期疗效及不良反应进行对比分析。结果观察组患儿的临床短期和长期疗效都明显优于对照组(P均<0.05)。结论孟鲁司特对小儿持续哮喘的临床治疗效果显著,值得临床推广应用。

Objective To analyze the clinical effect of montelukast in the treatment of children with persistent asthma. Methods 96 cases of children with mild to moderate persistent asthma in pediatric clinic of our hospital from March 2012 to May 2012 were selected a：C. randomly divided into two groups, with 48 cases in each group. Children in the control group received the routine comprehensive therapy （budesonide aerosol treatment）, while children in the observation group received the montelukast on the basis ofbudesonide aerosol therapy. The short-term efficacy, long-term efficacy and adverse reactions were analyzed and compared between two groups. Results The short-term efficacy and long-term efficacy of children in the observation group was significantly better than those in the control group, and the differences between two groups were statistically significant （all P〈0.05）. Conclusions Montelukast has significant effect in the treatment of children with persistent asthma, which is worthy of clinical promotion.