宫颈癌新辅助化疗临床疗效评价

Efficacy Evaluation of Neoadjuvant Chemotherapy for Cervical Cancer

目的:探讨早期宫颈癌新辅助化疗的疗效和安全性。方法:选择Ib1期至IIb期宫颈癌39例,采用DBM方案动脉灌注化疗1-2个疗程后,行腹腔镜下广泛性子宫切除术及盆腔淋巴结清扫术;观察化疗前后癌灶的变化、化疗副反应及术后病理结果等指标。结果:全部病例化疗后宫颈局部肿瘤直径均不同程度缩小,化疗有效率100%;3例IIb期宫旁病灶改善不满意直接行放疗,其余36例行腹腔镜下宫颈癌根治术;手术成功率100%;有12例(12/36)术后病理结果未发现癌灶。主要毒副反应为消化道症状及I-II度白细胞减少,用药后可缓解。结论:宫颈癌新辅助化疗近期疗效好,副反应轻。

Objective：To evaluate the response and security to neoadjuvant chemotherapy （ NACT） in patients of Ib1-IIb cervical cancer .Method：A retrospective study were made on 39 cervical cancer patients （ FIGO stage Ib1-IIb） underwent this DBM therapy by arterial infusion chemotherapy for 1 or 2 courses and followed by radical hysterectomy .The observation indexes included the change of the local lesion , side effect and pathological outcomes after the surgery .Result： All the patients indicated reduction of the lesions .the effective rate was 100%.Except 3 patients in IIb stage took radiotherapy , the rest take laparoscopic radical operation.The success rate of operation was 100%.There’re 12 （12/36） pathological reports showed that no cancer residue were detected .The main side effects were symptom of digestive tract like nausea and vomiting and I-II degree leucocytopenia .All these symptoms could be remittent after the symptomatic treatment .Con-clusion：Neoadjuvant chemotherapy （ NACT） is effective in short-term efficacy and the side effect is tolera-ble.