还原型谷胱甘肽治疗2型糖尿病合并脑梗死的临床观察

Clinical Study on Reduced Glutathione in Treatment of Type 2 Diabetes Complicated with Cerebral Infarction

目的:探讨还原型谷胱甘肽治疗2型糖尿病合并脑梗死的临床疗效。方法:将2型糖尿病合并脑梗死的患者56例随机分为治疗组和对照组各28例,对照组给予常规治疗,治疗组则在常规治疗基础上加用还原型谷胱甘肽,疗程14d。对比治疗前后血清TNF-α、HCY变化,并与20例健康体检者作为健康组进行比较,治疗前、后均进行NIHSS评分,计算治疗总有效率。结果:治疗前治疗组和对照组的TNF-α、HCY水平均高于健康组(P<0.05),治疗后两组TNF-α、HCY均降低,各自与治疗前对比均有显著性差异(P<0.05),治疗组TNF-α、HCY下降更明显,对比对照组差异有统计学意义(P<0.05);治疗组总有效率(89.3%)明显高于对照组(64.3%),对比差异有统计学意义(P<0.05)。结论:还原型谷胱甘肽可降低2型糖尿病合并脑梗死患者血清TNF-α、HCY水平,改善神经功能。

Objective：To investigate the clinical efficacy of reduced glutathione in treatment of type 2 diabetes complicated with cerebral infarction .Method： 56 patients with type 2 diabetes complicated with cerebral infarction were randomly divided into treatment group and control group , 28 cases in each group . The control group and the treatment group were given conventional treatment combined with reduced glutathi -one.The course of treatment was 14 days.Comparing the changes of serum TNF-α, Hcy before and after treatment, they were also compared with a healthy group , which included 20 healthy volunteers ,and scored by NIHSS before and after treatment , then calculated the total effective rate of treatment .Results： Before treatment , the TNF-α, Hcy of the treatment group and the control group were higher than the healthy group （P＆lt;0.05）.The TNF-α,Hcy of the treatment group and the control group decreased .Respectively compared with before treatment, they were significantly different （P＆lt;0.05）.The TNF-α,Hcy of the treatment group decreased more obviously , and it was significant difference compared with control group （ P＆lt;0.05）;The total effective rate of the treatment group （89.3%） was significantly higher than the control group （64.3%）, it was significantly different （P＆lt;0.05）.Conclusion： Reduced glutathione could reduce the TNF-α, Hcy in serum of type 2 diabetes complicated with cerebral infarction and improved the nerve function .