恶性胃肠道间质瘤免疫组化与电镜研究

Malignant Gastrointestinal Stromal Tumors:Immunohistochemical and Ultrastruastructural Studies

目的 探讨恶性胃肠道间质瘤 (GIST)的组织学起源与病理特点。方法 对 15例恶性GIST标本 ,运用电镜与免疫组化方法进行观察和对比分析。结果 大多数病例c kit与CD34标记阳性 ,电镜见瘤细胞树状突起、致密核心颗粒与间质丝团样纤维。结论 GIST符合卡哈尔间质细胞来源。超微结构病变特点与c kit。

Objective To explore the pathological characteristics and histogenesis of gastrointestinal stromal tumors(GIST). Methods Fifteen cases of GIST were observed and analyzed by immunohistochemistry and electron microscopy. Results There were dendritic like cytoplasm,dense core granules and skeinoid fibers in most tumor cells that were positively stained for c kit and CD34. Conclusions GIST originates from the interstitial cells of Cajal(ICC).Ultrastructural features and the expression of c kit and CD34 play an important role in diagnosis of GIST.