骨朗格罕斯细胞组织细胞增生症的细针吸取细胞学诊断

Diagnosis of Langerhans' Cell Histiocytosis by Fine Needle Aspiration Cytology

目的 探讨细针吸取细胞学 (FNAC)在术前诊断骨Langerhans细胞组织细胞增生症 (LCH)中的作用及意义。方法 用细针吸取采集肿瘤细胞涂片。经HE、Wright和免疫细胞化学染色、光镜观察 ,将术前FNAC结论与术后组织切片诊断进行对比分析。结果 细胞学诊断LCH 2 1例 ,其中 19例进行了手术切除及病理切片检查 ,细胞学诊断准确率为 94 7%。结论 骨LCH在FNAC检查中具有特征性细胞形态学改变 ,术前诊断准确率高 ,且方法简便、快速 。

Objective To study the role of preoperative fine needle aspiration cytology(FNAC)in the diagnosis of Langerhans' cell histiocytosis(LCH)of the bone. Methods FNAC smears were stained with H&E,Wright staining and immunohistochemistry and observed under light microscope. Results Twenty one cases of LCH were diagnosed by FNAC,in which 19 cases were confirmed by postoperative histological examination.The sensitive rate of FNAC in diagnosis of LCH was 94.7%. Conclusion FNAC is a rapid and useful technique for immediated diagnosis of LCH that allows concurrent therapy.