乳腺癌合并糖尿病患者血清胰岛素、瘦素及C反应蛋白的水平变化及意义

Research about serum insulin,leptin,C reactive protein in breast cancer combined with diabetes mellitus patients

目的研究乳腺癌合并2型糖尿病患者血清胰岛素、瘦素及C反应蛋白(CRP)的水平及意义。方法收集乳腺癌患者96例,分为乳腺癌合并糖尿病组(50例)和单纯乳腺癌组(46例);健康体检女性58例作为正常对照组,分别测定其空腹胰岛素、瘦素及CRP水平。结果乳腺癌合并糖尿病组和单纯乳腺癌组其血清胰岛素、瘦素及CRP水平较正常对照组明显升高(P<0.05或P<0.01),且乳腺癌合并糖尿病组三种指标水平明显高于单纯乳腺癌组(P<0.05)。乳腺癌合并糖尿病组血清胰岛素水平与瘦素、CRP呈正相关(r=0.481,0.579,P<0.01)。结论血清胰岛素、瘦素及CRP水平的升高可能促进2型糖尿病患者乳腺癌的发生。

Objective： To investigate the expressions of serum insulin, leptin and C reactive protein level in breast cancer combined with diabetes and study their clinical meaning. Methods： Ninety six cases of breast cancer patients were divided into diabetic patients with breast cancer group （50 cases ）, simple breast cancer group （46 cases ） and control group （58 cases）, and fasting insulin, leptin and C reactive protein level were measured. Results： In the cases of breast cancer combined with diabetes group and the pure breast cancer group, insulin, leptin and C reactive protein level in- creased significantly, leptin was positively related to insulin, and C reactive protein was positively related to leptin and in- sulin. Conclusion： There is the increase in insulin, leptin and C reactive protein in breast cancer occurrence and develop- ment, and the monitoring of the changes of three indexes may be significant in breast cancer.