消囊酊急性毒性试验研究

Study on acute toxicity experience of Xiao-nang Tincture

目的了解消囊酊单次给药后动物所产生的急性毒性反应,为临床安全用药及监测提供参考。方法采用Bliss法研究小鼠一次性灌胃不同剂量的消囊酊、消囊酊溶剂及其药物浓缩液后的急性毒性反应。结果消囊酊及其溶剂组给药后部分小鼠出现毒性反应,并出现死亡,死亡率随着给药剂量的增加而升高,消囊酊LD50为14.6 ml·kg-1,溶剂LD50为14.4 ml·kg-1;药物浓缩液的MTD为300 ml·kg-1,相当于临床用量的300倍。结论消囊酊具有一定的急性毒性,其毒性反应主要是由乙醇溶剂产生的急性酒精中毒症状。

Objective ： Study on the acute toxicity experience of Xiao -nang Tincture. Methods ： The acute toxicity of mice was evaluated by Bliss method. The survival station of mice was observed for 14 days after different dosages of Xiao - nang Tincture, solvent and concentrated solution of Xiao -nang Tincture were administrated orally. Results： The toxic reaction was observed in some mice of Xiao -nang Tincture group and solvent group. The excited state of central nervous system in mice was expressed in first. Then the state of central inhibition was observed. A part of mice falled asleep and some died from 4h after i.g. The mortality rate was rised with the increased of dosage. The LDs0 of Xiao - nang Tincture was 14.6 ml · kg^-1. The LDs0 of solvent was 14.4 ml · kg^-1. The toxic reaction wasn＇t observed in the group of concentrated solution of Xiao -nang Tincture and the Maximal Tolerance Dose （MTD） of it was 300 ml · kg^-1 that was equivalent to 300 times of clinical dosage. Conclusion ： Xiao -nang Tincture and its solvent have acute toxicity which were coused by alcohol. The ex- pression of toxic reaction charaterized by acute alcoholism.