摘要
目的探讨Bmi-1蛋白在胃癌组织中的表达及其与胃癌临床病理特征的关系。方法采用免疫组化ABC法检测98例胃癌和9例正常胃组织Bmi-1蛋白的表达。结果胃癌组织Bmi-1蛋白阳性率为75.5%,远高于正常胃组织中Bmi-1蛋白11.1%的阳性率,两组间差异有统计学意义(P<0.01)。结论 Bmi-1蛋白在胃癌组织中高表达,在细胞增殖、凋亡及癌变过程中有重要作用,此标记能客观表明胃癌的临床病理特征。
Objective To explore the expression of B-cell specific Moloney murine leukemia virus insertion site 1（Bmi-1）in gastric carcinoma（GC）tissue and its relationship with the clinicopathological features of GC. Methods Immunohistochemistry was used to detect the expression of Bmi-1 in 98 cases of GC and 9 cases of normal mu-cosa. Results The positive rate of Bmi-1 expression in GC cases was significantly higher than that in normal gastric mucosa（75.5% vs 11.1%, P〈0.05）. Conclusion High expression of Bmi-1 protein in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological charac-teristics of GC.
出处
《浙江中西医结合杂志》
2014年第4期301-302,F0003,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
