干扰素α致甲状腺功能异常21例临床分析

Clinical Analysis of 21 Patients with Thyroid Dysfunction Induced by Interferon Alpha

目的探讨干扰素α治疗慢性丙型病毒性肝炎（丙肝）时对甲状腺功能的影响及治疗对策。方法对我院2007年6月--2011年6月的309例慢性丙肝患者应用干扰素α治疗过程中出现甲状腺功能异常21例的临床资料进行分析。结果本组甲状腺功能异常发生率6．8％（21／309），21例在应用干扰素α治疗前甲状腺功能均正常，治疗2周-6个月后出现甲状腺功能异常，其中甲状腺功能亢进症（甲亢）11例，甲状腺功能减退症（甲减）7例，亚临床甲减3例。明确诊断后2例甲亢停用干扰素，余继续用药，同时予相应治疗，病情好转出院。随访半年，预后良好。结论干扰素α治疗慢性丙肝可诱发甲状腺功能异常，故治疗过程中应密切监测甲状腺功能，以及时采取处理措施。

Objective To investigate the effect on thyroid function and therapic methods of interferonα （IFNα） in treatment of chronic viral hepatitis type C. Methods Clinical data of 21 patients with thyroid dysfunction from 309 patients with chronic viral hepatitis type C received IFNα therapy during June 2007 and June 2011 was analyzed. Results The inci- dence rate of thyroid dysfunction was 6.8% （21/309） , and the patients had normal thyroid function before IFNα therapy. Thyroid dysfunction occurred 2 weeks to 6 months after treatment, including 11 patients with hyperthyroidism, 7 patients with hypothyroidism and 3 patients with subclinical hypothyroidism. After the diagnosis was confirmed, IFNα therapy was termina- ted in 2 patients, and the other patients continued IFNα therapy. All patients received corresponding treatment and were dis- charged after pathogenetic condition was improved. All the patients had excellent prognosis during a 6-month follow-up. Con- clusion IFNα in treatment of patients with chronic viral hepatitis type c may induce thyroid dysfunction, so clinicians should closely monitor thyroid function during IFNα therapy in order to give appropriate treatment.