期刊文献+

HIF-1α在非小细胞肺癌中的表达及研究进展 被引量:1

下载PDF
导出
摘要 通过回顾低氧诱导因子HIF-1α的研究历程,阐述低氧对HIF-1α的调控以及在肿瘤生长、发展过程中的作用,尤其是在非小细胞肺癌中的表达及其在治疗过程中的地位,揭示通过抑制HIF-1α及其通路达到治疗非小细胞肺癌的目的。
出处 《甘肃医药》 2014年第4期258-261,共4页 Gansu Medical Journal
基金 甘肃省技术研究与开发专项计划(项目编号:1105TCYA019)
  • 相关文献

参考文献25

  • 1Semenza GL,Agani F,Booth G,et al.Structural and functional anal- ysis of hypoxia-inducible factor l[J].Kidney int,1997,51:553-555.
  • 2Ke Q,Costa M.Hypoxia-inducible factor-1 (HIF-1) [J].Mol Pharmacol, 2006,70( 5 ) : 1469-1480.
  • 3Lee YK,Kim EJ,Lee JE,et al.Hypoxia induces con-nective tissue growth factor mRNA expression [J].J Ko-rean Med Sci,2009,24 (Suppl):S176-S182.
  • 4Liu YV,Baek JH,Zhang H,et al.RACK1 competes withHSP90 for binding to HIF-lalpha and is required for O2-independent and HSP90 inhibitor-induce d degrada-tion of HIF-lalpha[J].Mol Cell, 2007,25 ( 2 ):207-217.
  • 5Ullah MS,Davies AJ,Halestrap AP.The plasma mem branelactate transporter MCT4,but not MCTI,is up-regulated by hypoxia through a HIF-Ia lpha dependent mechanism [J]. J Biol Chem 2006,281(14):9030-9037.
  • 6Shimoda IA,Fallon M, Pisareik S.HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of in traeehular pH inpulmonary arterial myoeytes [J].Am J Physiol Lung Cell Mol Physio 1,2006,291 (5):941-949.
  • 7Weidemann A,Johnson RS.Biology of HIF-la lpha [J].Ce Death Diflet, 2008,15 (4):621-627.
  • 8Semenza GL.O2-regulated gene expression:transerip tional control of cardio respiratory hysiology by HIF-I[J]. J App I Physiol,2004,96 (3):1173-1177.
  • 9Zhong H,De Marzo AM,Laughner E,et al.Overexpression of hypoxiaindueible factor 1 alpha in common human cancers and their metastases [ J ]. Cancer Res, 1999,59 : 5830-5835.
  • 10Volm M, Koomagi R.Hypoxia-inducible factor and its relationship to apoptosis and proliferation in lung cancer [J]. Anticancer Res, 2000,20:1527-1533.

二级参考文献27

  • 1张咏梅,王朝卿,孙建锁,宋光耀.非小细胞肺癌组织中MRP1 mRNA和GST-π mRNA的表达及意义[J].中华肿瘤防治杂志,2007,14(12):913-916. 被引量:9
  • 2王永来,刘彩刚,陈双,黄铄.HIF-1α与VEGF在子宫内膜癌组织血管生成中的作用[J].中华肿瘤防治杂志,2007,14(15):1156-1158. 被引量:14
  • 3Harris AL. Hypoxia-a key regulatory factor in tumour growth.Nat Rev Cancer,2002,2(1) : 38-47.
  • 4Kaelin WG Jr. How oxygen makes its presence felt. Genes Dev,2002,16(12):1441-1445.
  • 5Nauck M, Karakiulakis G, Perruchoud AP, et al. Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells. Eur J Pharmacol, 19980341(2-3):309-315.
  • 6Machein MR, Kullmer J, Ronicke V, et al. Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells. Neuropathol Appl Neurobiol,1999,25(2):104-112.
  • 7Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia inducible factor 1alpha in common human cancers and their metastases. Cancer Res,1999,59(22) : 5830-5835.
  • 8Zagzag D, Zhong H, Scalzitti JM, et al. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer,2000,88(11) : 2606-2618.
  • 9Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem, 1993,268(29) : 21513-21518.
  • 10Neufeld G, Cohen T, Gengrinovitch S, et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J, 1999,13(1):9-22.

共引文献9

同被引文献10

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部