粉尘螨滴剂舌下含服治疗儿童过敏性哮喘的疗效

Efficacy of Dust Mite Sublingual Drops for the Treatment of Children with Allergic Asthma

【目的】探讨粉尘螨滴剂舌下含服对小儿过敏性哮喘的临床治疗效果及其对患儿肺功能指标的影响。【方法】将本院收治的125例变应原皮肤测试阳性患儿随机分为观察组（63例）及对照组（62例）两组。对照组患儿采用常规性抗过敏治疗，观察组患儿在对照组治疗的基础上舌下含服粉尘螨滴剂，观察比较两组患儿临床疗效及肺功能指标变化。【结果】观察组患儿呼吸困难、咳嗽、肺部啰音等临床症状改善时间显著优于对照组，且两组相比较差异有显著性（ P ＜0．05）。两组患儿治疗前临床症状评分，肺功能指标相比较差异无显著性（P ＞0．05），治疗后两组患儿临床症状评分，肺功能指标较治疗前均有改善，且观察组改善效果优于对照组，差异均有显著性（ P ＜0．05）。【结论】舌下含服粉尘螨滴剂能有效提高过敏性哮喘患儿临床治疗效果，改善患儿肺功能，有利于患儿预后。

[Objective] To explore clinical efficacy of dust mite sublingual drops for the treatment of chil-dren with allergic asthma and its impact on lung function indices .[Methods]A total of 125 children with aller-gen skin test-positive in our hospital were randomly divided into observation group （ n=63） and control group （ n = 63） .The control group received conventional anti-allergy treatment ,while the observation group re-ceived dust mite sublingual drops based on the treatment of control group .Clinical efficacy and the changes of lung function indices in two groups were observed and compared .[Results]Dyspnea ,cough ,pulmonary rales and other clinical symptoms in observation group were markedly better than those in control group ,and there were significant differences（ P〈0 .05） .There was no significant difference in clinical symptom score and lung function indices before treatment between two groups （ P 〉0 .05） .Compared with before treatment ,clinical symptom score and lung function indices in two groups after treatment were improved ,and the improvement of observation group was better than the control group ,and there was significant difference（ P〈0 .05） .[Conclu-sion]Dust mite sublingual drops can effectively increase clinical therapeutic effect of allergic asthma in pediat-ric patients and improve lung function ,so it is helpful for the prognosis of pediatric patients .