羟苯磺酸钙联合奥美沙坦治疗糖尿病肾病伴蛋白尿疗效观察

Observation of the Efficacy of Calcium Dobesilate Combined with Olmesartan for the Treatment of Proteinuria in Diabetic Nephropathy

【目的】探讨羟苯磺酸钙联合奥美沙坦治疗糖尿病肾病（DN ）的蛋白尿临床效果。【方法】将2012年2月至2013年4月就诊于本院的DN伴蛋白尿患者70例，随机分为观察组（35例）和对照组（35例）。对照组采用奥美沙坦等降血糖、降血脂、降血压等常规治疗，观察组在对照组基础上添加羟苯磺酸钙治疗。对比两组治疗前及治疗12周后患者的24 h尿白蛋白排泄率（UAER）、单核细胞趋化蛋白-1（MCP-1）、尿α1-微球蛋白（α1-MG）水平。【结果】治疗12周后24hUAER观察组下降更为明显，差异具有统计学意义（ P ＜0．05）。观察组治疗总有效率为88％，显著高于对照组的68％，差异具有统计学意义（ P ＜0．05）。【结论】羟苯磺酸钙联合奥美沙坦治疗DN的蛋白尿有良好疗效，安全性好。

[Objective]To explore the clinical efficacy of calcium dobesilate combined with olmesartan for the treatment of proteinuria in diabetic nephropathy （DN） .[Methods]A total of 70 DN patients with proteinu-ria in our hospital from Feb .2012 to April 2013 were randomly divided into observation group （ n =35） and control group（ n=35） .The control group received regular treatment including olmesartan and other hypogly-cemic hypotensive treatment .The observation group was additionally given calcium dobesilate based on the treatment of control group .The 24h-urinary albumin excretion rates（UAER） ,monocyte chemotactic protein-1 （MCP-1） and urinary α1-microglobulin（α1-MG） before and 12 weeks after treatment were compared between two groups .[Results] The 24h-UAER in observation group after 12 weeks of treatment was decreased more obviously ,and there was significant difference（ P 〈0 .05） .The total effective rate of observation group was 88% ,which was markedly higher than that of control group（68% ） ,and there was significant difference（ P〈0 .05） .[Conclusion]Calcium dobesilate combined with olmesartan for the treatment of proteinuria in DN has good efficacy and safety .