雷公藤多苷片制粒工艺研究

Tripterygium wilfordii glycosides slice granulating technology more research

目的解决雷公藤多苷片在制粒过程中粉尘飞扬大,压片操作困难,易出现松片、花斑等质量问题。方法通过对所用辅料用量比例的调整,制粒工艺的改进,考察制得片子的外观性状、崩解时限、脆碎度等质量指标的差异。结果增加赋形剂、润滑剂的用量,将乙醇湿法制粒改为处方中原有辅料糊精浆喷雾干燥制粒。结论增加了片重,提高了片子的硬度,有效解决松片、花斑等质量问题。

Objective Solve the tripterygium wilfordii glycosides tablets in granulating process of the dust float in the sky in the pelleting operation difficulty, easy to appear quality problem such as pine, tinea. Methods Through the excipients used dosage proportion of adjustment, Granulating process improvements, Review made film appearance, disintegration time limit, the difference of the quality indicators such as brittle broken degrees. Results Increased excipients, the usage of lubricant, To instead of ethanol granulator prescription in the original accessories dextrin pulp spray drying granulating. Conclusion Increase the piece weight,To improve the hardness of the film,Effective to solve the quality problem of the loose pieces, tinea, etc.