摘要
目的对国内 4厂家罗红霉素胶囊进行体外溶出度测定。方法采用分光光度法测定罗红霉素胶囊的体外溶出度 ,并对溶出参数进行相关性分析。结果 4厂家生产的罗红霉素胶囊溶出度参数有显著性差异 (P <0 .0 1)。结论建议厂家对产品进行溶出度检查 ,以控制其内在质量 。
ObjectiveThe dissolution of roxithromycin capsules manufactured by four different factories was tested.MethodsThe dissolution of roxithromycin capsules was analyzed with spectrophotometry. The dissolutive parameters of different products were compared.ResultsSignificant differences in dissolutive parameters among the four products from different factories could be found.ConclusionThe dissolubility of products should be tested to control the quality and ensure clinical efficacy.
出处
《河北医科大学学报》
CAS
2001年第1期24-25,共2页
Journal of Hebei Medical University
关键词
罗红霉素
胶囊
溶出度
分光光度法
紫外线
roxithromycin
capsules
dissolution
spectrophotometry,ultraviolet
