银杏叶制剂对早期老年性痴呆者认知功能的影响

Effect of Gingo biloba on Cognition of Patients at the Early Stage of Alzheimer Disease

目的 :研究银杏叶制剂对老年性痴呆临床前期认知功能减退的防治作用。方法 :采用Benton视觉保持测验进行治疗前后对比研究。结果 :显示老年性痴呆临床前期人群中已存在认知功能减退 ,表现为正确分减少、错误分增多。错误以主图遗漏、变形、旋转和辅图的持续及遗漏为主 ,并与认知功能减退程度相关 ,服药三个月后 ,轻异组中正确分提高人数达 6 0 98%与降分者比较具有非常显著差异 (p <0 0 0 1) ,错误分下降例数达 5 6 %与增加者比较也具显著差异 (p <0 0 5 ) ,达正常标准者由原来的 7人增加至 15人 (p <0 0 5 )。结论 :通过信度和效度良好的视觉保持测验 。

Objective: To study the effect of Gingo biloba on cognition of patients at the early stage of Alzheimer disease Method: 180 subjects were screened for Alzheimer disease 45 patients (male 40, female 5) at the early stage of Alzheimer disease were assessed by Benton Visual Retention Test before and after treatment with gingo biloba Result: Before treatment, patient group showed some defect in cognitive function: less correct score, more error After treatment with gingo biloba for 3 months, 61% patients had correct score increased (p<0 001), 56% had error decreased (p<0 05) Conclusion:Gingo biloba can improve the cognitive function of patients at early stage of AD