肺癌手术前后血清STNFRI变化的临床意义

目的 研究肺癌患者手术前后血清STNFRI的变化。方法 采用ELISA方法测定了80例肺癌患者 ,14例非肿瘤患者 ,61例志愿健康成年人。结果 肺癌患者中STNFRI的平均水平明显高于健康对照组和非肿瘤组 (P<0.01)。按肿瘤TNM分期 ,肺癌Ⅲ～Ⅳ期患者远高于Ⅰ～Ⅱ期升高幅度 ,与疾病分期明显相关 ,而与病理类型无关 (P<0.01)。结论 排除自身免疫疾病和感染 ,STNFRI的测定对肿瘤的诊断 ,筛选 ,预后有辅助意义。也可了解病人的异常免疫状态 ,为肿瘤患者的免疫治疗提供依据及观察指标。

Objective To detect the serum levels of STNFR I in lung cancer patients. Methods The serum STNFR I was measured by ELISA. 80 lung cancer patients, 14 non-tumor patients and 61 healthy volunteers were involved in our study. Results The serum STNFR I in lung cancer patients was higher significantly than healthy control group and non-tumor group (p<0.01). The levels of STNFR I varied with stages of cancer, but were irrelative with pathology of tumors. The serum levels of STNFR I in stage III-IV tumors was higher than that in stage I-II tumors (p<0.01). Conclusion Detection of serum STNFR I was of high value in the screening and diagnosis of lung cancer. It also helped to understand the abnormal immune states of patients, and provided a basis for immnotherapy.