Kartagener综合征呼吸道症状2例诊治分析

Respiratory tract complications of Kartagener syndrome:two case report

目的探讨Kartagener综合征呼吸道症状的有效治疗措施及日常管理。方法回顾性分析2例Kartagener综合征患者临床资料并结合文献复习,分析Kartagener综合征呼吸道症状的病因、诊断和治疗方法。结果Kartagener综合征患者因基因突变致纤毛结构和功能异常,从而出现慢性鼻窦炎、支气管扩张、内脏反位三联征,针对其呼吸道症状的有效治疗可能减轻支气管、肺疾病的发展。结论Kartagener综合征的呼吸道症状应予以终生治疗,及早确诊并选择最合适的治疗方式,有益于疾病的转归。

Objective To explore the appropriate treatment and management in respiratory tract complications of Kartagener syndrome .Methods Retrospective analysis of clinical data of patients with Kartagener syndrome in two cases and review literature , analysis of the cause of Kartagener syndrome , respiratory symptoms , diagnosis and treatment .Results Kartagener syndrome due to mutations caused by abnormal structure and function of cilia , which appeared chronic sinusitis , bronchiectasis , situs inversus triad , may relieve bronchial effective treatment for their respiratory symptoms , lung disease de-velopment .Conclusion Kartagener syndrome should be lifelong treatment , early diagnosis and choose the most appropriate treatment, beneficial outcome of the disease .