术前血清CEA水平对结直肠癌术后复发的预测价值

Prognostic Value of Preoperative Serum Carcinoembryonic Antigen Level in Predicting Recurrence of Colorectal Cancer after Radical Surgery

目的探究术前血清癌胚抗原(CEA)水平与结直肠癌术后复发的关系。方法回顾性分析164例结直肠癌根治术治疗的患者,跟踪随访上述病例并分析相关临床病理学指标及术前CEA水平同复发的关系。结果 CEA升高组的术后复发率较高(54.9%),与CEA正常组相比,差异有统计学意义(P<0.05)。多因素分析表明,术前血清CEA水平、肿瘤分期与结直肠癌术后复发率阳性相关(P=0.003).结论术前血清CEA水平是预测结直肠癌术后复发问题的独立指标,术前血清CEA水平对结直肠癌根治术患者的治疗计划是有指导意义的。

Objective To evaluate the prognostic value of preoperative serum carcinoembryonic antigen （CEA） level in patients with colorectal cancer. Methods This retrospective study included 164 colorectal cancer patients aged from 25 to 69 years, surgically treated between April 2006 and October 2009. Correlation between postoperative recurrence and clinic pathological features or preoperative serum CEA levels was analyzed. Results Comparing with the normal CEA group, postoperative recurrence rate in elevated CEA group （54. 9% ） increased significantly （P 〈 0. 05 ）. Multivariate analysis indicated that both preoperative serum CEA levels and tumor stage correlated positively to postoperative recurrence rate of colorectal cancer patients （ P = 0. 003 ）. Conclusion Preoperative serum CEA is a reliable predictor factor for recurrence in patients with colorectal cancer. CEA might be used in treatment planning in colorectal cancer patients undergoing curative resection.