中老年女性精神分裂症患者血浆一氧化氮检测及临床意义

Measurement of plasma nitric oxide(NO) in middle and senior female schizophrenia and its clinical significance.

目的 :探讨血浆一氧化氮 (NO)与中老年女性精神分裂症之间的关系。方法 :运用硝酸还原酶法对 2 7例中老年精神分裂症患者的血浆 NO含量进行检测 ,并与正常对照组比较。结果 :中老年女性精神分裂症患者的血浆 NO含量 (4 5 .38± 2 5 .6 7)μmol/ L高于正常对照组 (33.44± 15 .5 5 )μm mol/ L ,但无显著性意义 (t=1.842 ,P>0 .0 5 ) ;以阳性症状为主的患者血浆 NO含量为 (4 9.95± 31.18)μmmol/ L ,以阴性症状为主的患者为 (4 0 .0 4± 16 .2 6 )μmmol/ L ,均高于正常对照组 ,但仅前者与正常对照组差异有显著性 (t=2 .0 5 9,P<0 .0 5 ) ;阳性症状组和阴性症状组间差异无显著性 (t=0 .996 ,P>0 .0 5 )。血浆 NO的含量与年龄、病程、家族史等无关。结论 :NO可能在中老年女性精神分裂症发病机制中起一定作用。

Objective:To explore the relationship between middle and senior female schizophrenia and nitric oxide(NO).Methods:Plasma NO levels were measured in 27 middle and senior female schizophrenics and 20 controls.Results:They showed that the plasma NO level of schizophrenia group was higher than those in control group,but no significantly difference[(45.38±25.67)μmmol/L and (33.44±15.55)μmmol/L separately, P >0.05]the plasma NO level of positive symptom group[(49.95±31.18)μmmol/L]was significantly higher than those in control group( P <0.05);there were no significantly difference between the negative group[(40.04±16.26)μmmol/L]and the control group( P <0.05).Conclusions:Nitric oxide might be in the pathogenesis of middle and senior female schizophrenia [