硫酸锌对高脂喂养ApoE基因敲除小鼠肝脏抗氧化作用的研究

下载PDF

导出

摘要肝脏是人体参与糖脂代谢的重要器官,而氧化损伤是造成肝脏损伤的原因之一.目前我国居民的高脂肪摄入逐渐增多,而高脂肪饮食会造成机体的氧化损伤^[1],所以研究补锌对高脂喂养小鼠肝脏的抗氧化作用具有重要意义.

作者蒋金金王慧峰汤嘉宁郭亮梁华山

出处《中国药物与临床》 CAS 2014年第4期454-455,共2页 Chinese Remedies & Clinics

基金太原市科学技术发展计划项目(11016224)

关键词抗氧化作用小鼠肝脏高脂喂养基因敲除 ApoE 硫酸锌氧化损伤高脂肪饮食

参考文献6

1陈永松,李玉光,赵晓云.高脂饮食对大鼠胰岛素抵抗及氧化损伤指标的影响及意义[J].山西医药杂志,2007,36(8):675-677. 被引量：3
2Sasaki T,Kuzuya M,Nakamura K,et al. AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the sup- pression of cathepsin S activity in apoE-deficient mice [J]. Atherosclerosis, 2010,210(2) :430-437.
3Shankar AH,Prasad AS. Zinc and immune function: the biologi- cal basis of altered resistance to infection [J]. Am J Clin Nutr, 1998,68(2 Suppl) :447S-463S.
4Salgueiro MJ,Zubillaga MB, Lysionek AE, et al. The role of Zinc in the growth and development of children [J]. Nutrition,2002, 18(6) :510-519.
5Sutherland DE,Stillman MJ. The "magic numbers" of metalloth- ionein[J]. Metallomics,2011,3(5) :444-463.
6Palmiter RD. Regulation of metallothionein genes by heavy met- als appears to be mediated by a Zinc-sensitive inhibitor that in- teracts with a constitutively active transcription factor, MTF-1 [J]. Proc Natl Aead Sei USA, 1994,91(4) : 1219-1223.

1Stern MP.Diabetes and cardiovascular disease:the “common” hypothesis.Diabetes,1995,44:369-374.
2Ghatta S,Srinivasan K,Kaul CL,et al.A study on alpha-adrenoceptor mediated contractile responses of high fat diet fed rat thoracic aorta.Pharmazie,2005,60:142-146.
3Srinivasan K,Patole PS,Kaul CL,et al.Reversal of glucose intolerence by pioglitazone in high fat diet fed rats.Methods Find Exp Clin Pharmacol,2004,26:327-333.
4Viswanad B,Srinivasan K,Kaul CL,et al.Effect of tempol on altered angiotensin Ⅱ and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance.Pharmacol Res,2006,53:209-215.
5De Fronzo RA,Tobin JD,Andres R.Glucose clamp technique:a method for quantifying insulin secretion and resistance.Am J Physiol,1979,237:E214-223.
6Paolisso G,Esposito R,D' Alessio MA,et al.Primary and secondary prevention of atherosclerosis:is there a role for antioxidants? Diabetes Metab,1999,25:298-306.
7Maechler P,Jornot L,Wollheim CB.Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.J Biol Chem,1999,274:27905-27913.
8Williamson JR,Cooper RH.Regulation of the citric acid cycle in mammalian systems.FEBS Lett,1980,117:K73-K85.
9Maritim AC,Sanders RA,Watkins JB 3rd.Diabetes,oxidative stress and antioxidants:a review.J Biochem Mol Toxicol,2003,17:24-38.

1林潭发,陈永松.血红素氧合酶-1改善胰岛素抵抗的作用机制研究进展[J].中国药物与临床,2009,9(1):52-55.
2王继勇,高云丽,左洛,何敏,陈聪,李小军.高糖高脂饮食诱导大鼠胰岛素抵抗模型和评价[J].中南民族大学学报（自然科学版）,2013,32(1):54-57. 被引量：10

中国药物与临床

2014年第4期

内容加载中请稍等...