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家蚕丝胶对糖尿病大鼠肾脏胞外信号调节激酶信号转导通路活性的影响 被引量:4

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摘要 糖尿病肾病(diabetic nephropathy,DN)是糖尿病的严重并发症,其病理特征是肾小球肥大,系膜细胞增生、细胞外基质(extracellular matrix,ECM)积聚和基底膜增厚,从而导致肾小球高滤过和蛋白尿,最终导致肾小球硬化和肾间质纤维化.近年来有研究显示胞外信号调节激酶(extracellular signal regulated kinase,ERK)信号转导通路与DN密切相关.ERK是丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)家族的一个亚族,可被多种生长因子和细胞因子激活,介导细胞的生长、增殖和分化等多种生理、病理过程[1,2].本研究旨在探讨家蚕丝胶对糖尿病模型大鼠肾脏ERK信号转导通路的影响及可能机制,以期为临床治疗DN提供新思路.
作者 刘美琴
出处 《中国药物与临床》 CAS 2014年第4期460-461,共2页 Chinese Remedies & Clinics
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参考文献8

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