摘要
铜绿假单胞菌是一种常见的条件致病菌,也是引起院内感染的主要致病菌之一。由于铜绿假单胞菌具有先天和后天获得耐药性,其对多种抗生素包括碳青霉烯类抗生素的耐药率不断上升,临床治疗越来越困难。铜绿假单胞菌的耐药机制复杂,包括β-内酰胺酶的产生、主动外排系统的表达、外膜蛋白的缺失、氨基糖苷钝化酶的产生、药物作用靶位改变、整合子的存在、生物被膜的形成等。
Pseudomonas aeruglnosa(PA) is a common opportunistic pathogen as well as one of the main pathogens causing nosocomial infections. The clinical treatment of PA infection is becoming difficult gradually for its congenital and acquired drug resistance and its increasingly high resistance rate of many antibiotics including carbapenem. Mechanisms of drug resistance of PA are complex, which include production ofβ-lactamases, expression of active efflux systems, lack of outer membrane proteins, production of aminoglycoside modifying enzymes, changes of antimicrobial targets, existence of integrons, and biofilms forming, etc.
出处
《微创医学》
2014年第2期200-203,共4页
Journal of Minimally Invasive Medicine
基金
广西自然科学基金(桂科自2010GXNSFA013172)
广西区卫生厅科研项目(桂卫Z2010371)
关键词
铜绿假单胞菌
耐药机制
多重耐药
综述
Pseudomonas aeruginosa
Resistance mechanisms
Multi-drug resistant
Review