摘要
目的 研究不同部位大肠癌肝转移分布情况 ,并为治疗方法及途径提供依据。方法 根据肠系膜上、下动脉供血范围 ,以脾曲为界 ,将大肠分为左、右两半 ,分别观察各半大肠癌在肝左、右两叶转移分布情况。结果 肠系膜上、下静脉及脾静脉在汇入门静脉后 ,血液未充分混合 ,存在流线型分流 ,影响肝转移的分布。右半大肠癌患者肝转移主要转移至肝右叶 ,约占 87.9% (5 8/ 6 6 ) ;左半大肠癌患者肝转移则随机转移至肝左、右两叶。乙状结肠癌发生肝转移者占大肠癌伴肝转移患者的 6 9.3% (2 0 3/ 2 93) ,与原发于其它部位的大肠癌比较有极显著差异 (P<0 .0 1)。结论 右半大肠癌肝转移主要转移至肝右叶 ,左半大肠癌肝转移则随机转移至肝左、右两叶。乙状结肠癌极易发生肝转移。除经肝动脉化疗外 ,经门静脉系统化疗可能更合理。
Objective To study the distribution of metastatic cancer sites in liver of different loctions of colorectal carcinoma as a guide for treatment. Methods According to the blood supply from the superior a and inferior mesenteric arteries we used the splenic flexure as the middle coordinate and divided the large intestine into right and left two halves and then the sites of metastatic cancers were observed carefully. Results When the venous blood streams from the superior and inferior mesenteric veins entered the portal vein they were not well mixed. This phenomina influenced the distribution of the metastatic lesions: primary cancer in right half of large intestine metastasied to right lobe of liver in 87.9%(58/66) of cases, and left half primary cancers metastasised to both right and left lobes of liver without regular rule. Cancers of sigmoid colon had high rate of liver metastases of 69.3% in total number of colorectal carcinoma with liver metastasis (203/293). Conclusion The results of this study suggest that besides chemotherapy given through hepatic artery, the portal vein route of administration of chemotherapeutic drugs may be more reasonable and effective
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第1期61-62,共2页
Tumor
关键词
大肠肿瘤
肿瘤转移
门脉系统
Colorectal neoplams
Neoplasm metastasis
Portal system
