摘要
目的 探讨慈菇对CCl4 致大鼠肝纤维化的干预作用。方法 对 5月龄Wistar大鼠 ,用CCl4 染毒致大鼠形成肝组织纤维化 ,以ELISA法和放射免疫分析法检测大鼠血清cyfra2 1 1和CEA的浓度的变化 ,并观察慈菇的干预效果。结果 染毒组大鼠cyfra2 1 1和CEA明显高于对照组 ,慈菇可减轻CCl4致大鼠肝纤维化程度并减少cyfra2 1 1和CEA的产生。 结论 大鼠肝纤维化后血清cyfra2 1 1和CEA升高 。
Objective In order to investigate the implication of dynamic changes of cyfra21 1 and CEA in rats of experimental liver fibrosis.Methods The rat models of liver fibrosis were induced by CCl\-4.cyfra21 1 and CEA in serum and cultured peritoneal macrophages were measured at 12 week.Histological changes were analyzed by pathological method.Results As the liver fibrosis was developed,the cyfra21 1 and CEA were increasing.Especially,the cyfra21 1 and CEA level in serum and degree of liver fibrosis of experimental group with Sagittaria sagittifolia was significantly decrased compare with positive control group.Conclusions The results suggest that cyfra21 1 and CEA could be reaction the damage of liver fibrosis and Sagittaria agittfolia could reduce the degree of damage.Sagittaria agittifolia is worthy of exploiting as the healthful diet for human.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2001年第1期19-21,共3页
Chinese Journal of Public Health
基金
1999年度福建省教委科研基金资助
关键词
慈菇
肝纤维化
肽碎片类
癌胚抗原
sagittaria sagittifolia
liver fibrosis
peptide fragment
carcinoembryoic antigen