二硫化碳接触对粘胶工人血清铜、锌和硒含量的影响

The Effects of the Exposure to CS_(2) on Serum Copper,Serum Zinc and Serum Selenium of Workers in the Viscose Rayon Factory

目的 探讨CS2 接触与血清微量元素铜、锌、硒之间的关系 ,为CS2 接触致心血管系统疾病的毒作用机理提供依据。方法 选择某化纤厂纺丝车间年龄在 45岁以下 ,接触CS2 5年以上 76名CS2 作业工作为接触组 ;在同一工厂棉浆车间选择曾经接触过CS2 但现在已停止CS2 接触 5年以上的 33名工人作为干预组 ;从未接触过CS2 的 2 3名工人作为对照组进行流行病学横断面调查。结果 接触组SCu、SZn和SSe含量均低于对照组 (P =0 0 0 0 1) ;多元逐步回归分析进一步显示 ,CS2 对SCu、SZn和SSe含量均有负贡献 (偏回归系数 β分别为 -10 4173,- 8 973和 - 15 5 0 98)。结论 提示CS2 接触能降低血清铜、锌。

Objective To explore the relation between CS 2 exposure and the trace elements of serum copper,serum zinc,serum selenium,provide the basis for the mechanism of toxicity effects of CS 2 on cardiovascular system disease.Methods In filature workshop of a viscose rayon factory we selected 76 workers with age below 45 years old and touchtime to CS 2 beyond 5 years as exposure group;In cotton plasm workshop of the same factory selected 33 workers who once touched CS 2 but now have been kept away from CS 2 more than 5 years as intervention group;and selected 23 workers who had never touched CS 2 as control one,and the epidemiological cross sectional investigation was carried out.Results SCu,SZn and S Se of exposure group were all lower than control one (P=0.001).In multivariable stepwise regression,we discovered that exposure to CS 2 caused negative contributions on SCu,SZn,and SSe(partial regression coefficients β are separately -10.417,-8.9735 and -15.5098).Conclusion The results suggested CS 2 exposure could reduce the levels of Scu,SZn and S Se .