从血管内皮细胞的分泌功能探讨温病气分证与微观血瘀相关性的实验研究

Experimental Study on Relativity Between Oifen Syndrome and Microcosmic Blood Stasis from Secrerive Function of Vaso-endothelial Cells in Seasonal Febrile Disease

目的 :从血管内皮细胞的分泌功能探讨温病气分证与微观血瘀的相关性。方法 :实验采用大肠杆菌内毒素从家兔耳缘静脉注射造成温病气分证模型 ,观察模型组病理学、血管内皮细胞的分泌功能的改变。结果 ,模型组光镜下肺脏有微血栓存在 ,且模型组动物出现 t- PA/PAI、NO/ET、TXB2 /6-酮 - PGI1α平衡破坏。结论 :温病气分证存在微观血瘀 ,温病气分证微观血瘀形成机理可能与内皮细胞释放的血管活性物质 ,如ET/NO、t- PA/PAI、TXB2 /6-酮 - PGI1α之间的平衡失调有关。

Objective:To observe the mechanism of relativity between Qifen syndrome and microcosmic blood stasis from secrerive function of vaso endothelial cells in seasonal febrile disease (SFR).Method:Qifen syndrome in SFR model was induced by colibacillary endotoxin via auricular intravenous injection.The change on pathomorphology,secrerive function of vaso endothelial cells in seasonal in the model was observel.Result:It showed the existence of microthrombus in the lung via microscope in the model,It also indicated that the balance destruction of t PA/PAI、HO/ET、TXB 2/6 ? 睵GI 1α .Conclusion:Qifen syndrome in SFR model exist microcosmic blood stasis,The mechanism of microcosmic blood stasis may be related to the balance destruction of t PA/PAI、NO/ET、TXB 2/6 ? 睵GI 1α which was emitted by endoehelial cells.