建立小鼠黄褐斑实验动物模型的初步研究

Development of a Experimental Model of Chloasma in Mice

目的 :建立小鼠黄褐斑动物实验模型。方法 :用黄体酮注射液 (高、低两个剂量组 )攻击雌性小鼠 1个月 ,以皮肤、肝脏组织酪氨酸、MDA含量变化及皮肤黑色素细胞病理形态学指标作为考察模型是否成功的依据。结果 :酪氨酸、MDA明显升高 ,皮肤黑色素沉着增加。结论 :黄体酮攻击雌性小鼠所致的黄褐斑动物实验模型获得成功。

Objective:to create a experimental moolel of chloasma in female mice.Methods:after musculal injection of progesterone at high and low dosage for one month in female mice,tyrosine and MDA in skin and liver were measured,and skin melanocyte was observed. Results:tyrosine and MDA Significantly rose and the deposit of melanin in skin increased.Conclusion:the model of chloasma in female mice can be induced by the administration of pyogesterone.