依脉特灵治疗急性脑梗塞的疗效观察

The Curative Effect of Isotetrandrine on Acute Cerebral Infarction

本文对依脉特灵(Isotetrandrine IT)治疗急性缺血性脑卒中(脑梗塞)的疗效进行对比统计分析,其显效率为78％,总有效率为91％,明显优于对照组,且无明显毒副作用,表明依脉特灵对缺血性脑梗塞是行之有效的具有应用前景的药物。

To search for way of cure of acute cerebral infarction, a method of combination of Traditional Chinese and Western Medicine was used in clinical practice, Isotetrandrine was an active principle abstracted from Chinese herbal medicine root that was first used to treat acute cerebral infarction. We studied 94 patients, 64 males and 30 females, with an average age of 65.5 years (51 to 88), who were classified into three group. 31 patients were in group A and B respectively, and 32 patients in group C. In order to evaluate the curative effect, we compared the changes of clinical symptoms and signs, cerebral CT, CET and hemorrheology of treatment group with that of control group. The results showed that effective rates were 55%, 61%, 78% in group A, B, C respectively, and total effective rates were 86%, 87%, 91% respectively. It suggested that the group C was the highest response. rate. There were non obvious toxicity and side effect. The results indicate that isotetranlrine is an optimal drug for treatment of the ischemic cerebral infarction. The mechanism of action might be to antagonize the calcium.