原发性高血压110例血浆心房利钠因子水平的观察

Observation of the Plasma Atrial Natriuretic Factor Level in 110 Patients with Essential Hypertension

本文报告30例健康人及110例原发性高血压患者血浆心房利钠因子(ANF)水平及其与高血压性心脏病、原发性高血压的肾素分型,疾病分期及巯甲丙脯酸治疗前后的关系。结果表明,健康人及患者组基础值均显著高于激发值;患者组基础值显著高于健康组;高心病组显著高于非高心病组;低肾素型组显著高于正常肾素型及高肾素型组;使用巯甲丙脯酸治疗后,血浆ANF水平显著低于治疗前;但与原发性高血压病情的严重程度则无明确的关系。原发性高血压血浆ANF水平的升高,主要与心、肺血容量的变化密切相关。

We reported the plasma level of atrial natriuretic factor (ANF) in 110 patients with essential hypertension (EH) and the relationship of the plasma ANF level with hypertensive heart disease (HHD), EH renin typing and hypertension siaging. The results showed that: 1. The basal levels of plasma ANF in healthy persons and the EH group were significantly higher than the level provoked by furosemide(P<0.001). 2.The basal level of plasma ANF in the EH group was significantly higher than in healthy subjects (P<0.001). 3. The basal level of plasma ANF in the HHD group was significantly higher than in the non-HHD group(P<0.001). 4.The basal level of ANF in patients of low PRA type was significantly higher than in patients of normal or high PRA type (P<0.001). Thus, we believe that a significant increase of plasma ANF in EH is mainly related to the change of the heart lung plasma volume.