尼群地平长期治疗老年收缩期高血压的疗效观察

The Therapeutic Effect of Long-Term Nitrendipine in Old Systolic Hypertension

本文用随机双盲法对44例(治疗组29例,对照组15例)老年收缩期高血压(OSH)患者口服尼群地平(NTP)与安慰剂进行长期(15.66±5.6月)治疗观察。结果:NTP治疗Ⅰ、Ⅱ期OSH有效率为93.1％,其收缩压和舒张压下降幅度均高于对照组,日服NTP5～10mg有55.17％患者获满意疗效,故NTP小剂量、长疗程是OSH较理想的一种药物疗法。

Forty four old systolic hypertension (OSH) patients were recieved doubleblind randomized treatment with nitrendipine (NIP) and placebo in long-term (7-14 months) studies.The results showed that the antihypeensive efficacy of NTP to the phase Ⅰ, Ⅱ EH patients is definite, the response rate was 93.1%. SBP was decreased from 176.34±12.75 to 146. 90±9.78mmHg, the decrease in DBP from 84.21±7.00 to 77.31±6.51mmHg. 55.17% of patients had a 'good to excellent' response to 5-10mg of NTP once daily. There was a significant decrease in serum glucose (P<0.03) total cholesterol and uric aid (P<0.01) after NTP, and the creatinine was not influenced (P>0.05). Only 1.37% of patients had the mild side-effects. Therefore, the results indicate that a small dose of NTP can be used effectively and safely in long-term treatment of OSH.