铝在氟中毒病因中的地位实验研究

Experiment Study on the Role of Aluminum in the Pathogenesis of Fluorosis

Wistar大鼠212只,经36周慢性实验发现,饲料中加入氟化物后,使大鼠骨氟、铝均显著升高。骨氟与骨铝呈极显著正相关。表明氟能促进食物中自然铝的吸收和蓄积;发现氟斑牙发生率和严重程度及肾功能损害程度与氟铝联合作用有关。提示,氟中毒时很可能伴有铝在体内蓄积和发生作用。因此,首次提出铝是氟中毒的病因之一,在一定条件下氟铝联合作用是发生氟中毒的重要条件。

Two hundred and twelve Wistar rats were divided into two groups. In the first group the rats (169) were fed with the food on a high level of natural aluminum(Al, 152ppm) and were divided into 6 sub-groups. (1) Control, (2) fluoride (F) (3) aluminum (Al) , (4) F-Al, (5) Al ip+F orally, and (6) Al ip groups. The rats (43) in the second group were fed with the food on a low level of natural Al (28ppm) , and were divided into 4 subgroups; (1)control, (2) F, (3) Al, and (4) F-Al groups, The F, the F-Al and the Al ip+F orally group were administered with sodium fluoride which was mixed with the food (containing F 300Ppm). The Al and the F-Al groups were administered with aluminum chloride mixed with the food (containing Al^(3+) 150ppm). The Al ip+F orally, and the Al ip groups were injected with AlCl_2·6H_2O(10mg/kg. wt. day) through the peritoneal cavity. The experiment lasted 36 weeks. We found that the bone F and bone Al were raised obviously in the groups with adding fluoride and that there was a significant positive correlation between them. It was shown that fluoride can promote the absorption and accumulation of the natural aluminum originated from the food in the bones. The severity of dental fluorosis and the degree of the kidney function impairment were related to a combined the effect of F-Al. Based on the result, we suggest that aluminum plays a role in the pathogenesis of fluorosis. The combined effect of F-Al is an important condition for occurring of fluorosis.