γ-氨基丁酸样神经元胞体和终末在前庭神经核簇的免疫组织化学定位

Immunohistochemical Localization of GABA-Containing Neuronal Somata and Terminals in the Vestibular Nuclei of the Monkey and Cat

ABC法研究猴、猫前庭神经核簇(VN)内含Y-氨基丁酸(GABA)神经元胞体和终末的分布。小型GABA免疫反应阳性神经元主要位于前庭神经内侧核(MVN)头侧半和y群腹侧部。散在于神经网的阳性终末亦呈类似分布趋势。前庭神经外侧核(LVN)尾背侧部阴性的大型神经元胞体和近端树突周围有密集的阳性终末。猴前庭神经上核(SVN)和MVN头端等处的一些中型阴性神经元亦被阳性终末环绕,提示绒球小结叶对前庭眼肌反射的调节。

The distributions of GABA-immunoreactive (GABAir) cell bodies and terminals (fine puncta) were studied in the vestibular nuclei (VN) of the squirrel monkey and cat using antiserum to GABA and ABC procedure. All the GABAir neurons in VN were small. They were mainly found in rostral part of the medial vestibular nueleus(MVN) and ventral 'y', as were the scattered GABAir terminals in neurapil. GABAir terminals surrounded somata and proximal dendrites of the unstained giant cells in dorsocaudal part of the lateral vestibular nucleus (LVN) . GABAir terminals also outlined a few unstained medium-sized neurons in central regiou and dorsal part of the superior vestibular nucleus (SVN), ventrolateral part of rostral MVN, rostrodorsal part of the inferior vestibular nucleus (IVN) and dorsal 'y' in monkey, thereby suggesting the modulation of the vestibulo-ocular reflexes by GABAergic fibers from the flocculonodular lobule.