抗乙肝新药拉米夫定的研究进展

Recent research progress in lamivudine,a new anti HBV agent

拉米夫定是新一代核苷类抗乙肝药物 ,可通过降低乙型肝炎病毒 (HBV)依赖RNA的DNA多聚酶生物活性 ,明显抑制HBV DNA的合成 ,具有作用强、安全、不良反应少等特点 ,是治疗不同类型的乙型病毒性肝炎的新选择。本文就拉米夫定的化学性质、药代动力学特点、作用机制、临床应用。

Lamivudine is a new kind of anti hepatitis B agent from nucleosides.It inhibits the DNA synthesis of HBV via decreasing the bio activity of DNA polymerase that depended on RNA.It may be useful in treatment of all kinds of hepatitis B.Its chemical properites,pharmacokinetic feature,mechanism of action,clinical uses,adverse drug reactions,and drug resistance are reviewed.