无症状乙型肝炎病毒表面抗原携带者血清HBV复制指标的检测

Detection of the HBV Replicative Markers in Serum of Asymptomatic HBsAg Carriers

对96例无症状HBsAg携带者(ASC)的血清乙型肝炎病毒脱氧核糖核酸(HBV DNA)、DNA多聚酶(DNA P)、乙型肝炎病毒核心抗原(HBcAg)和e系统作了检测,80例献血员作为正常对照。结果发现,ASC组HBV DNA阳性者22例(22.9％),其中e抗原阳性者HBV DNA检出率为45.8％(11/24),HBeAg阴性者为15.5％(11/71)。DNAP阳性率39.5％(38例)。HBcAg的阳性率最高达81.3％(78例),且与HBeAg、HBV DNA、DNA P活力间有显著的正相关性。表明血清HBV DNA与HBeAg关系密切。提示血清HBcAg的检测,可作为判断HBV复制、ASC传染性的可靠指标。

The levels of serum HBV DNA, DNA polymerase, HBcAg and e system were assayed in 96 asymptomatic HBsAg carriers (ASC). These components in 80 donors served as control. Results showed that 22 out of 96 ASC(22.9%) was positive for HBV DNA. The positive rate of HBV DNA varied from 45.8% to 15.5% dependency of who was serologically positive or negative for HBeAg. DNA P values increased in 38 from all ASC(39.5%). The detective rate of HBcAg were up to 81.3% and showed a remarkly plus relation to HBeAg, HBV DNA and DNA P activity. These results indicate that there was a close combination between HBV DNA and HBeAg. It might be assumed that HBcAg in serum could be used the direct marker to decide whether the HBV replication exist or not in ASC.