摘要
目的 :观察丹酚酸A(SA A)抗肝细胞过氧化损伤时在抑制肝星状细胞 (HSC)增殖中的作用。方法 :以不同浓度的丙二醛 (MDA)刺激HSC ,通过氚标胸腺嘧啶 (3H[TdR])掺入法 ,观察对HSC增殖作用 ,以及SA A对损伤肝细胞MDA含量及促HSC增殖的影响。结果 :一定浓度的MDA有促进HSC增殖的作用 ;损伤肝细胞MDA含量明显增加 ;SA A可抑制损伤肝细胞对HSC的促增殖作用 ,并可降低损伤肝细胞MDA的含量。结论 :SA A可通过抗肝细胞过氧化损伤抑制HSC的增殖。
Objective:The inhibiting action of Salvianolic Acid A on proliferation of HSC was observed under the conditions of antiperoxide injury.Methods:HSC was stimulated by different concentration MDA.The proliferation of HSC was assayed by 3H incorporation.At the same time the effects of Salvianolic Acid A on the content of MDA in injured hepatocyte were observed.Results:Certain concentration MDA could promote the proliferation of HSC.The content of MDA was increased in injured hepatocyte. Salvianolic Acid A could inhibit the promoting action of HSC proliferation induced by injured hepatocyte and reduce the content of MDA in injured hepatocyte.Conclusion:Salvianolic Acid A can inhibit the proliferation of HSC by antiperoxide injury of hepatocyte.
出处
《中国中西医结合消化杂志》
CAS
2001年第1期15-16,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
上海市教委曙光计划资助项目 (No .95SG2 6 )
关键词
肝损伤
丹酚酸A
脂质过氧化
丙二醛
肝星状细胞
Liver injury
Salvianolic Acid A
Lipid peroxidation
Malonyldialdehyde
Hepatic stellate cell
