视盘炎和球后视神经炎患者血清OPN、IL-18、TNF-α变化及意义

Changes and significance of serum OPN, IL-18, TNF-α in patients with papillitis and retrobulbar neuritis

【目的】探讨视盘炎和球后视神经炎患者血清骨桥蛋白(osteopontin,OPN)、白细胞介素-18(interleukin-18,IL-18)、肿瘤坏死因子(tumor necrosis factor-α,TNF-α)水平变化及意义。【方法】选择近几年来确诊的视盘炎患者11例和球后视神经炎16例为两组观察组,同期体检健康的11人为对照组,采用酶联免疫吸附法检测患者血清OPN、IL-18、TNF-α进行分析。【结果】两观察组OPN、IL-18、TNF-α结果均高于对照组,两观察组组间比较差异有统计学意义(P<0.01)。【结论】视盘炎和球后视神经炎患者的病情与血清OPN、IL-18、TNF-α水平变化呈正相关,为评估视盘炎和球后视神经炎患者病情变化及转归提供有效的依据。

[ Objective ] To discuss the changes and significance of serum osteopontin （OPN） and interleukin-18 （IL-18） and tumor ne- crosis factor-α（TNF-α ） in patients with papillitis and retrobulbar neuritis. [Method] 11 patients with papillitis and 16 patients with retrohulbar neuritis were chosen as two observation groups, and 11 healthy persons were regarded as the control group. Serum OPN, IL- 18, TNF-α were detected and compared between groups through ELISA. [ Result] The result of OPN, IL-18, TNF-α in both observa- tion groups was higher than that in the control group, and there was statistically significant difference between the two observation groups （P 〈 0.01） [ Conclusion ] The changes of Serum OPN, IL-18, TNF-α changes were positively related to the condition of pa- tients with papillitis and retrobulbar neuritis, which provides effective basis for the state change and development of the patients.