粉防己有效成分的药理活性研究进展

Advance on Studiy of Chemical Components,Pharmacological Effect of Stephania tetrandra

对重要粉防己的药理活性进行文献整理与分析。粉防己的主要成分是粉防己碱和防己诺林碱,在中医中常用来作为抗高血压、抗风湿及镇痛药等。近年来,关于其化学研究、药理活性研究均取得了重要进展。粉防己药理研究发现其具有广泛的药理活性,药理实验及临床报道药理活性包括抗肿瘤、抗肿瘤细胞多药耐药、神经保护等多个方面,为粉防己的临床应用提供了丰富的研究资料。通过文献整理,总结了粉防己不同活性成分单体的药理活性及作用机制,为该药临床研究提供理论依据,进而为其开发利用提供依据。

The stephania tetrandra,which contains tetrandrine and fangchinoline,is traditionally used as ananalgesic,antirheumatic,and antihypertensive drug in China.Recently,chemical composition and pharmacological activities of stephania tetrandra have been widely reported.Pharmacological experiments and clinical reports show that stephania tetrandra has multiple pharmacological activities,including anti-tumor,altered muhidrug resistance,neuroprotection and so on.Based on the research literature,this review will focus on recent developments concerning the pharmacology of stephania tetrandra,it shows a good prospect to make good use of its effective components.