辛伐他汀治疗脑梗死的临床观察

Clinical observation of simvastatin for the treatment of cerebral infarction

目的:观察辛伐他汀对脑梗死患者血脂水平及神经功能恢复的影响。方法:将60例随机分为观察组及对照组各30例,对照组给予常规治疗,观察组在常规治疗基础上给予辛伐他汀20 mg/次,1次/d,口服,疗程为半年,分别于入院后第1天、治疗半年后检测2组总胆固醇(TC)、甘油三酯(TG)、高密度胆固醇(HDL)、低密度胆固醇(LDL)水平。结果:治疗半年后观察组总胆固醇、甘油三酯和低密度胆固醇水平较对照组明显降低,高密度胆固醇较对照组升高。结论:他汀类药物可明显改善脑梗死的预后,同时能降低TC、TG、LDL水平降低,改善血管功能,降低再发病率。

Objective：To observe the effect of Simvastatin on the blood lipid level and Neural functional recovery in cerebral infarction Datients.Methods：The cerebral infarction patients were divided into two groups randomly ,Control group received routine treatment ,and observation group received 20 mg Simvastatin once a day totally for 6 months in addition to routine treatment .The levels of blood lipid ,total cholesterol （ TC） , triglyceride （ TG） , high density cholesterol （ HDL） , low density cholesterol （ LDL） levels were detected at admission , and 6 months after treatmen .Results：The levels of total cholesterol （ TC） , triglyceride （ TG） and low density cholesterol （ LDL ） decreased significantly in observation group and the levels of high density choIesterol （HDL） increased significantly in Control group （P＆lt;0.05）. Conclusion：Statins could obviously improve the prognosis of cerebral infarction, and can reduce the TC, TG, LDL levels, improve blood vessel function , reduce the incidence of a disease .