MFN2、Survivin和nm23在卵巢癌中的表达及其意义

Expressions and significances of mitofusin-2,Survivin and nm23 in ovarian cancer

目的:探讨MFN2、Survivin和nm23在卵巢癌中的表达及意义。方法:用免疫组化法检测MFN2、Survivin和nm23在不同卵巢组织中的表达情况。结果:①MFN2阳性染色定位于胞质,呈棕黄色颗粒,与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组MFN2累积光密度值高表达,差异有统计学意义(P<0.05)。②survivin阳性染色主要位于呈棕黄色颗粒的细胞核,与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组survivin的累积光密度值表达率呈上升趋势,差异均有统计学意义(P<0.05)。③nm23阳性染色主要位于细胞基质中,为棕黄色细颗粒,nm23在恶性卵巢癌组的累积光密度值呈上升趋势,差异均有统计学意义(P<0.05)。结论:MFN2、Survivin和nm2在恶性卵巢癌组织中表达上调,与卵巢癌淋巴结转移和临床病理分期密切相关。

Objective： To explore the expressions and significances of mitofusin -2, Survivin and nm23 in ovarian cancer. Meth- ods： The expressions of mitofusin - 2, Survivin and nm23 in different ovarian tissues were detected by immunohistochemistry assay. Re- suits ： The positive staning of mitofusin - 2 was yellow brown grains which were presented mainly in cytoplasm. Compared with normal ovari- an tissue and benign ovarian tumor, integral optic density （IOD） expression of mitofusin -2 was high in malignant ovarian cancer group, there was statistically significant difference （ P 〈 0. 05 ） . The positive staning of Survivin was yellow - brown grains which were presented mainly in cell nucleus. Compared with normal ovarian tissue and benign ovarian tumor, IOD expression rate of Survivin showed an increasing trend, there was statistically significant difference （ P 〈 0. 05 ） . The positive staning of nm23 was yellow brown grains which were presented mainly in cytoplasm. IOD expression of nm23 showed an increasing trend, there was statistically significant difference （ P 〈 O. 05 ） . Con- clusion： Up - regulations of mitofusin - 2, Survivin and nm2 in malignant ovarian cancer are closely correlated with lymph node metastasis and clinicopathological stage of ovarian cancer.