纳洛酮与氨茶碱联合治疗小儿急性呼吸衰竭的临床疗效观察

Observation on the clinical efficacy of naloxone combined with aminophylline in treatment of children with acute respiratory failure

目的:观察临床中小儿急性呼吸衰竭采取纳洛酮与氨茶碱联合用药的治疗效果。方法:选取100例小儿急性呼吸衰竭患儿分为对照组和观察组各50例,对照组患儿给予常规治疗,观察组患儿给予纳洛酮与氨茶碱联合治疗,观察两组的临床治疗效果。结果:观察组临床治疗总有效率为94.0%,明显高于对照组的80.0%,两组差异有统计学意义(P<0.05);治疗前两组的PaO2、PaCO2、PH、SaO2指标比较差异无统计学有意义(P>0.05),治疗后两组PaO2、PaCO2、SaO2指标较治疗前有明显的改善,且组间差异有统计学意义(P<0.05)。观察组临床症状缓解时间、住院治疗时间均明显低于对照组差异有统计学意义(P<0.05);观察组不良反应发生率为0,对照组为12.0%,差异有统计学意义(P<0.05)。结论:临床中小儿急性呼吸衰竭采取纳洛酮与氨茶碱联合用药是可行的,能够有效地提高临床治疗效果,较快改善患儿的临床症状和血气指标,缩短住院治疗时间,治疗的安全性高,值得临床中应用推广。

Objective： To observe the clinical efficacy of naloxone combined with aminophylline in treatment of children with acute respiratory failure. Methods： One hundred children with acute respiratory failure were selected and divided into control group and observa- tion group, 50 children in each group; the children in control group were treated with routine therapy, while the children in observation group were treated with naloxone combined with aminophylline; the clinical efficacies in the two groups were observed. Results： The total effective rate in observation group was 94. 0%, which was statistically significantly higher than that in control group （ 80. 0% ） （ P 〈 0.05 ） ; before treatment, there was no statistically significant difference in PaO2, PaCO2 , pH value and SaO2 between the two groups （ P 〉 0.05 ） , after treatment, PaO2 , PaCO2 and SaO2 were improved significantly, and there was statistically significant difference between the two groups （P 〈 0. 05 ） . The remission time of clinical symptoms and hospitalization time in observation group were statistically significantly lower than those in control group （P 〈 0. 05 ） ; the incidence rates of adverse reactions in observation group and control group were 0 and 12. 0% , respective- ly, there was statistically significant difference between the two groups （ P 〈 0. 05 ） . Conclusion ： It is feasible to treat children with acute respiratory failure by naloxone combined with aminophylline, the method can effeetively improve the curative effect, rapid improve clinical symptoms and blood gas indexes, shorten hospitalization time and raise the safety, which is worthy of clinical application and promotion.