精神分裂症患者血清同型半胱氨酸水平与P300的相关

Study on Relativity between Serum Level of Homocysteine and Event-related Potential P300 in Schizophrenics Disorder

目的探讨精神分裂症患者血清同型半胱氨酸水平(Hcy)与事件相关电位P300的关系。方法随机将年龄在18~65岁之间符合CCMD-3精神分裂症诊断标准患者45例作为试验组,选择45例健康者作为对照组。同时采用酶联免疫法检测血清Hcy水平及以P300评定认知功能,并将结果加以分析、比较。结果与对照组相比,研究组CZ、PZ点N1、P2、N2、P3潜伏期均明显延长(t=2.36~3.86,P<0.05或0.01),研究组CZ、PZ点N2、P3波幅明显降低(t=3.06~5.27,P<0.01);研究组血清Hcy水平高于对照组(t=2.76,P<0.01);CZ、PZ点P300潜伏期与血清Hcy水平呈正相关(r=0.36~0.49,P<0.05或0.01),CZ、PZ点P300波幅与血清Hcy水平则呈负相关(r=-0.47^-0.51,P<0.01)。结论精神分裂症患者血清Hcy水平升高,其认知功能损害可能与血清Hcy代谢异常有关。

Objective To investigate the relativity between serum level of homocysteine and event-related potential P300 in schizo- phrenics disorder. Methods A total of 45 patients （among 18 -65 years old）met with CCMD -3 for schizophrenics disorder criteria were recruited as research group. 45 normal healthy person were selected as control group. Their serum level of homocysteine was meas- ured by enzyme immunoassays at the same time. Cognitive function was assessed with event-related potential P300. A comparison was made between the patients and the healthy subjects. Results The latencies of CZ and PZ were significantly longer in schizophrenics dis- order than in the normal controls （ t = 2.36 -3.86, P 〈 0.05 or 0.01）, the amplitudes of CZ and PZ were significantly lower in schizo- phrenics disorder than those in the normal controls （t = 3.06 -5.27, P 〈 0.01 ）. Their serum level of homocysteine in schizophrenics dis- order was significantly higher than that in the normal controls （t = 2.76, P 〈 0.01 ）. The latency of CZ and PZ were positively correlated with serum level of homocysteine（ r = 0.36 -0.49 ,P 〈0.05 or 0.01 ）. The amplitude of CZ and PZ were negatively correlated with ser- um level of homocysteine （ r = -0.47 ~ -0.51, P 〈 0.01 ）. Conclusion The serum level of homocysteine in schizophrenics disorders is in- creased, and cognitive functions disorders may be related to the homocvsteine metabolism imbalance.