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C-erbB-2蛋白在贲门癌中的表达及其与预后的关系 被引量:1

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摘要 目的探讨C-erbB-2蛋白在贲门癌中的表达及其与预后的关系。方法应用免疫组化二步法检测200例贲门癌组织中C-erbB-2蛋白的表达情况,结合病理资料及临床资料进行分析。结果贲门癌组织中C-erbB-2蛋白的阳性表达率为31.5%。C-erbB-2蛋白的过表达与肿瘤浸润深度、分化程度、淋巴结转移及临床分期密切相关。结论 C-erbB-2蛋白的表达水平与肿瘤组织的分化程度和术后临床分期密切相关,是贲门癌预后的一项判断指标。
出处 《中国肿瘤外科杂志》 CAS 2014年第2期103-105,共3页 Chinese Journal of Surgical Oncology
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  • 1Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence [J]. Clin Cancer Res ,2007,13 (15 Pt 1) :4429-4434.
  • 2Hoffmann M, Stoss 0, Shi D, et al. Assessment of a Her-2 scoring system for gastric cancer: results from a validation study [J] . Histopathology ,2008,52(7) : 797 -805.
  • 3Zhou XX,Ji F,Zhao JL,et al. Anti-cancer activity of anti-pl85 HER -2 ricin A chain immunotoxin on gastric cancer cells [J] . J Gastroenterol Hepatol,2010,25(7) :1266-1275.
  • 4邵永孚,韩少良,刘秀萍,梁毕科.中期胃癌nm23、p21和c-erbB-2基因的表达及其临床意义[J].癌症,2000,19(9):922-926. 被引量:13
  • 5Meza JJ,Au HJ,Sawyer MB. Trastuzumab for gastric cancer [J]. Expert Opin Biol Ther,2009,9(12) :1543-1551.
  • 6Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target [J]. Ann Oncol, 2008 , 19 (9) :1523-1529.
  • 7Janehne J, Urrnacher C, Thaler HT, et al. Expression of HER2 Pneu oncogene product P185 in correlation to clinicopa_thological and prognostic factors of gastric carcinoma [J]. Cancer Res Clin Oncol,1992,118(6) :474-497.
  • 8陈斌,罗荣城,崔斐,钱新宇.胃癌HER-2/neu基因表达与预后的相关性[J].南方医科大学学报,2006,26(3):344-347. 被引量:44
  • 9Petrelli NJ, Winer EP, Brahmer J, et al. Clinical Cancer Advances 2009: major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology[J].J Clin Oncol,2009,27(35) :6052-6069.

二级参考文献18

  • 1张声,叶圣华,林华.P53和P21过表达与胃癌淋巴结转移呈正相关[J].中国肿瘤临床,1996,23(9):639-643. 被引量:6
  • 2李宁 祝庆孚.C-erbB-2和P53基因产物增强表达与胃癌生物学行为和预后关系[J].中华外科杂志,1994,32(9):558-558.
  • 3Kim Y J,J Surg Oncol,1993年,54卷,3期,167页
  • 4Schechter AL, Hung MC, Vaidyanathan L. The neu gene: an erbB-homologous gene distinct from and unlinked to. the gene encoding the EGF receptor[J]. Science, 1985, 229(4717): 976-8.
  • 5Sugano K, Ushiama M, Fulentomi T, et al. Combined measurement of the c-erbBo2 protein in breast carcinoma tissues and sera is useful as a sensitive tumor marker for monitoring tumor relapse [J]. Int J Cancer, 2000, 20, 89(4): 329-36.
  • 6Stahl P, Kissau L, Mazitschek R, et al. Total synthesis and biological evaluation of the nakijiquinones [J]. Am Chem Soc, 2001, 123(47): 11586-93.
  • 7Potti A, Ganti AK, Koch M, et al. Identification of HER-2/neu over-expression and the clinical course of lung carcinoma in non-smokers with chronic lymphocytic leukemia[J]. Lung Cancer, 2001, 34(2):227-32.
  • 8Delektorskaya W, Perevoshchikov AG, Kushlinskii NE. Immuno-histological study of NM 23 and C-erbB-2 expression in primary tumor and metastases of colorectal adenocarcinoma [J]. Bull Exp Biol Med, 2003, 135(5): 489-94.
  • 9Orr MS, O'Connor PM, Kohn KW. Effects of c-erbB-2 overexpression on the drug sensitivities of normal human mammary epithelial cells[J]. J Nat Cancer Inst, 2000, 92(12): 987-94.
  • 10Oya M, Yao T, Tsuneyoshi M. Expressions of cell cycle regulatory gene products in conventional gastric adenomas: possible immunohistochemical markers of malignant transformation [J].Hum Pathol,2000, 31 (3): 279-87.

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